18: 2008 Honda Civic
The Honda Civic is naturally one of the most reliable cars on the road. Darrell “Doc” Gould got his Civic over the million-mile mark driving 4000 miles a week. “Doc estimates that he drives about 4000 miles a week, currently splitting the mileage between his Honda Civic and a 2009 Honda Odyssey minivan he uses for larger loads. He spends much of his time driving a route that takes him from his home near Kansas City, Missouri, to St. Louis and Des Moines, Iowa. Doc prefers long hauls to short trips.” – via Consumer Guide

Doc of course makes a good point about scheduled maintenance on the car. It never pays off to be cheap when it comes to owning a car. Doing the maintenance will save a lot of heartache in the long run. The Civic is probably the most well-known economy car in the world. That obviously helps drivers expect a reasonable amount of reliability.