12: Cadillac CTS-V
In the 2000s, Detroit was making a change and GM was at the forefront of that change. The company was repositioning the Cadillac brand with a complete overhaul. The design language was Art & Science and the Cadillac models were distinctly different. The CTS-V was a huge departure for the Cadillac brand. The beautifully-sculpted sedan had something even more special under the hood (via The Drive).
The CTS-V was powered by the same engine and transmission that you’d find in a Corvette. This was the first Cadillac model with a six-speed manual transmission. The CTS-V is a notable car still popular today. GM has released many different incarnations of the CTS-V but the design language has stayed the same.